Prestimulation parameters predicting live birth in anovulatory WHO Group II patients undergoing ovulation induction with gonadotrophins
Identifieur interne : 000D75 ( Main/Exploration ); précédent : 000D74; suivant : 000D76Prestimulation parameters predicting live birth in anovulatory WHO Group II patients undergoing ovulation induction with gonadotrophins
Auteurs : A. Nyboe Andersen [Danemark] ; A. H. Balen [Royaume-Uni] ; P. Platteau [Belgique] ; G. Pettersson [Danemark] ; J.-C. Arce [Danemark]Source :
- Human Reproduction [ 0268-1161 ] ; 2010-08.
Abstract
BACKGROUND The objective of this study was to identify baseline predictors of live birth in anovulatory patients undergoing ovulation induction, and based on these predictors, develop nomograms for estimation of the probability of live birth in a single cycle. METHODS Univariate and multivariate logistic regression were used for retrospective analysis of clinical, sonographic and endocrinological parameters collected prior to the start of ovarian stimulation in a cohort of anovulatory World Health Organization (WHO) Group II patients (n 335), who were resistant to clomiphene citrate (CC) and therefore stimulated with gonadotrophins using a low-dose step-up protocol. RESULTS The univariate analysis identified age [OR 0.91 (95 CI: 0.840.98), P 0.015], duration of infertility [OR 0.71 (95 CI: 0.560.91), P 0.007], serum follicle stimulating hormone (FSH) concentration at the start of stimulation [OR 0.83 (95 CI: 0.690.99), P 0.034] and menstrual cycle pattern (P 0.022) as significant predictors of live birth. Baseline concentrations of luteinizing hormone, androgens, glucose and insulin, as well as body mass index, were not predictors of live birth. In the multivariate analysis, duration of infertility, FSH and menstrual cycle pattern were independent predictors, and nomograms were designed with these three parameters for individual prediction of the probability of live birth. CONCLUSIONS The chances of live birth in women with WHO Group II anovulatory infertility resistant to CC undergoing ovulation induction with gonadotrophins is highly influenced by the menstrual cycle pattern. Increases in duration of infertility and concentration of FSH (within the normal range) before the start of stimulation have negative influences on the likelihood of achieving a live birth.
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DOI: 10.1093/humrep/deq142
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Nyboe Andersen</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>The Fertility Clinic, Section 4071, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Danemark</country></affiliation></author><author><name sortKey="Balen, A H" sort="Balen, A H" uniqKey="Balen A" first="A. H." last="Balen">A. H. Balen</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Obstetrics & Gynaecology, Leeds General Infirmary, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Platteau, P" sort="Platteau, P" uniqKey="Platteau P" first="P." last="Platteau">P. Platteau</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>UZ Brussel, Centre for Reproductive Medicine, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Pettersson, G" sort="Pettersson, G" uniqKey="Pettersson G" first="G." last="Pettersson">G. Pettersson</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Ferring Pharmaceuticals A/S, Reproductive Health, Global Clinical & Non-Clinical R&D, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Arce, J C" sort="Arce, J C" uniqKey="Arce J" first="J.-C." last="Arce">J.-C. Arce</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Ferring Pharmaceuticals A/S, Reproductive Health, Global Clinical & Non-Clinical R&D, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Reproduction</title><idno type="ISSN">0268-1161</idno><idno type="eISSN">1460-2350</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2010-08">2010-08</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1988">1988</biblScope><biblScope unit="page" to="1995">1995</biblScope></imprint><idno type="ISSN">0268-1161</idno></series><idno type="istex">CE2176ED3EE805DDF1B3B1E9AA0C790D0417EEE8</idno><idno type="DOI">10.1093/humrep/deq142</idno><idno type="ArticleID">deq142</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0268-1161</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">BACKGROUND The objective of this study was to identify baseline predictors of live birth in anovulatory patients undergoing ovulation induction, and based on these predictors, develop nomograms for estimation of the probability of live birth in a single cycle. METHODS Univariate and multivariate logistic regression were used for retrospective analysis of clinical, sonographic and endocrinological parameters collected prior to the start of ovarian stimulation in a cohort of anovulatory World Health Organization (WHO) Group II patients (n 335), who were resistant to clomiphene citrate (CC) and therefore stimulated with gonadotrophins using a low-dose step-up protocol. RESULTS The univariate analysis identified age [OR 0.91 (95 CI: 0.840.98), P 0.015], duration of infertility [OR 0.71 (95 CI: 0.560.91), P 0.007], serum follicle stimulating hormone (FSH) concentration at the start of stimulation [OR 0.83 (95 CI: 0.690.99), P 0.034] and menstrual cycle pattern (P 0.022) as significant predictors of live birth. Baseline concentrations of luteinizing hormone, androgens, glucose and insulin, as well as body mass index, were not predictors of live birth. In the multivariate analysis, duration of infertility, FSH and menstrual cycle pattern were independent predictors, and nomograms were designed with these three parameters for individual prediction of the probability of live birth. CONCLUSIONS The chances of live birth in women with WHO Group II anovulatory infertility resistant to CC undergoing ovulation induction with gonadotrophins is highly influenced by the menstrual cycle pattern. Increases in duration of infertility and concentration of FSH (within the normal range) before the start of stimulation have negative influences on the likelihood of achieving a live birth.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Danemark</li><li>Royaume-Uni</li></country><region><li>Hovedstaden</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bruxelles</li><li>Copenhague</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Nyboe Andersen, A" sort="Nyboe Andersen, A" uniqKey="Nyboe Andersen A" first="A." last="Nyboe Andersen">A. Nyboe Andersen</name></region><name sortKey="Arce, J C" sort="Arce, J C" uniqKey="Arce J" first="J.-C." last="Arce">J.-C. Arce</name><name sortKey="Nyboe Andersen, A" sort="Nyboe Andersen, A" uniqKey="Nyboe Andersen A" first="A." last="Nyboe Andersen">A. 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